meso-Acetoxymethyl BODIPY Dyes for Photodynamic Therapy: Improved Photostability of Singlet Oxygen Photosensitizers.

LINCOLN R; DURANTINI AM; GREENE LE; MARTINEZ SR; KNOX R; BECERRA M C; COSA G

Photochemical and Photobiological Sciences

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2016

1474-905X

e report two BODIPY based photosensitizers (Br2BOAc and I2BOAc) featuring an acetoxymethyl substituent at the meso-position. These photosensitizers show improved photostability against singlet oxygen,when compared to a BODIPY photosensitizer lacking the acetoxymethyl group. Both compounds wereevaluated for photodynamic therapy against HeLa cells and photodynamic inactivation against E. coli bacteria. We show that the compounds readily embedded in the lipid membranes of HeLa cervical cancer cells and efficiently induced light-dependent apoptosis at nanomolar concentration. Also, both compounds showed a substantial degree of photoinactivation of E. coli bacteria when used at lowmicromolar concentrations.