NATES SILVIA VIVIANA
Artículos
Título:
Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection
Autor/es:
ISA MB; PAVÁN G; SICILIA DON P; GRUTADAURIA S; MARTINEZ L; GIORDANO MO; MASACHESSI G; BARRIL P; NATES S
Editorial:
CAMBRIDGE UNIV PRESS
Referencias:
Lugar: Cambridge; Año: 2014 vol. 142 p. 1708 - 1708
Resumen:
ittle is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P=0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P=0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P=0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles im