Resumen:
urpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver
eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls.
Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues.
Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve
of normal tension glaucoma patients (NTG).
Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2
and protein-bound citrulline.