Mouse plasma progesterone level is affected by different dietary omega-6/omega-3 ratios

OLIVA LL; SANTILLÁN ME; RYAN LC; BIANCONI S; VINCENTI LM; MARTINI AC; PONZIO MF; STUTZ G

HORMONE AND METABOLIC RESEARCH

GEORG THIEME VERLAG KG

Año: 2014 vol. 46 p. 120 - 120

0018-5043

n imbalance in the dietary polyunsaturated fatty acids (PUFAs) ω6/ω3 ratio, could negative influence reproductive performance. Objective: to assess the effects of chronic administration of diets enriched with soybean or sunflower oils with different ω6/ω3 ratios on the reproductive parameters of adult female mice. Material and Methods: mice were fed different diets for 90 days: a commercial diet (CD), a 5 or 10% soy oilenriched diet (SOD5 and SOD10, respectively), and a 5 or 10% sunflower oil-enriched diet (SFOD5 and SFOD10, respectively). The parameters evaluated were: body weight and food intake, estrous cycle, plasma progesterone concentration, ovulation rate, and oocyte quality. Results: progesterone concentrations (ng/ml) were significantly higher in the SFOD10: 14.9±2.8 vs CD: 5.4±1.2; SOD5: 5.6±1.1 and SFOD5: 4.6±1.4. Additional parameters evaluated were not affected. However, metestrous and luteal phases were shorter in subjects receiving SOD a