Ghrelin inhibited serotonin release from hippocampal slices

GHERSI MARISA; CASAS S; ESCUDERO C; VALERIA CARLINI; BUTELER F; CABRERA JR; HELGUI SCHIÜOTH; SUSANA RUBIALES DE BARIOGLIO

ELSEVIER SCIENCE INC

Año: 2011 vol. 32 p. 2367 - 2367

div class="cit">Ghrelin (Ghr) is a peptide produced peripherally and centrally. It participates in the modulation of different biological processes. In our laboratory we have shown that (a) Ghr administration, either intracerebroventricular or directly into the hippocampus enhanced memory consolidation in a step down test in rats (b) the effect of Ghr upon memory decreases in animals pretreated with a serotonin (5-HT) reuptake inhibitor, Fluoxetine, suggesting that Ghr effects in the hippocampus could be related to the availability of 5-HT. It has been demonstrated that Ghr inhibits 5-HT release from rat hypothalamic synaptosomes. Taking in mint these evidences, we studied the release of radioactive 5-HT to the superfusion medium from hippocampal slices treated with two doses of Ghr (0.3 and 3nm/¦Ìl). Ghr inhibited significantly the 5-HT release in relation to those superfused with artificial cerebrospinal fluid (ACSF) (H=9.48, df=2, p¡Ü0.05). In another set of experiments, Ghr was in