Acute Ghrelin administration attenuated the hyperactivity in the open field induced by bilateral olfactory bulbectomy in mice

VALERIA PAOLA CARLINI; GUILLERMANO DANIELE; BUTELER FLORENCIA; GHERSI MARISA; MARINA PONZIO; ANA CAROLINA MARTINI; HELGI B. SCHIOTH; MARTA FIOL DE CUNEO; ANA LUCIO SEVERO RODRIGUEZ

ELSEVIER SCIENCE INC

Año: 2012 vol. 35 p. 160 - 160

p style="MARGIN: 0cm 0cm 10pt" class="MsoNormal">This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/µl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administra