Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake

VALERIA PAOLA CARLINI; CECILIA GAYDOU, ROMINA; HELGUI SCHIÜOTH; SUSANA RUBIALES,

REGULATORY PEPTIDES

Elsevier B.V

Año: 2007 vol. 140 p. 65 - 65

0167-0115

font face="AdvTTb8864ccf.B" size="1"> Abstract Ghrelin (Ghr) is an appetite stimulating hormone that is produced peripherally, by the stomach, and centrally as well. Previous investigations show that Ghr increases food intake and memory retention in rats, and that extra-hypothalamic structures, such as the hippocampus, participate in these effects. In the present work we analyzed the effect on food intake and memory retention induced by Ghr after serotonin (5-HT) availability modification at the serotoninergic synapses. Animals only treated with a selective serotonin reuptake inhibitor (SSRI), fluoxetine (FLU) 5 mg/kg or clomipramine (CLO) 2.5 and 5 mg/kg, showed a significant reduction in both food intake and memory retention. On the contrary, Ghr dministration induces a significant increase in food intake and a dose-dependent increase in short and long term memory retention. When the animals were treate