Diferenttial effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action

VALERIA PAOLA CARLINI; MARIA BELEN PORETTI; MATHIAS RASK-ANDERSEN; ROHIT CHABAN; MARINA PONZIO; RAHUL S SAWANT; SUSANA RUBIALES DE BARIOGLIO; HELGI B. SCHIOTH; MARTA FIOL DE CUNEO

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2012 vol. 38 p. 159 - 159

p style="MARGIN: 0cm 0cm 10pt" class="MsoNormal">Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on the mRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor ty