Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression.

MARIA BELEN PORETTI; RAHUL S SAWANT; MATHIAS RASK-ANDERSEN; MARTA FIOL DE CUNEO; HELGI B. SCHIOTH; PERÉZ MF; VALERIA PAOLA CARLINI

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2016 vol. 233 p. 1077 - 1077

0033-3158

educed vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression.Poretti MB1, Sawant RS2, Rask-Andersen M2, de Cuneo MF1, Schiöth HB2, Perez MF3, Carlini VP4.AbstractRATIONALE:In response to stress, corticotropin releasing hormone (CRH) and vasopressin (AVP) are released from the hypothalamus, activate their receptors (CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Overstimulation of this system has been frequently associated with major depression states.OBJECTIVE:The objective of the study is to assess the role of AVP and CRH receptors in fluoxetine and venlafaxine effects on the expression of depression-related behavior.METHODS:In an animal model of depression (olfactory bulbectomy in mice, OB), we evaluated the effects of fluoxetine or venlafaxine (both 10 mg/kg/day) chronic administration on depression-related behavior in t