Effects of dietary omega-3 PUFAs on growth and development: somatic, neurobiological and reproductive functions in a murine model

SANTIAGO BIANCONI; MARIA EMILIA SANTILLÁN; MARIA DEL ROSARIO SOLIS; ANA CAROLINA MARTINI; MARINA FLAVIA PONZIO; LAURA MARÍA VINCENTI; HELGI B SCHIÖTH; VALERIA PAOLA CARLINI; GRACIELA STUTZ

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2018

0955-2863

mega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective:to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups´ developmentand reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient(sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver + 2.8% soybean) diet before conception and throughoutgestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic,neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning periodand shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P