Autor/es:
MOTRICH, RUBEN; CASTRO, GONZALO MANUEL; CAPUTTO, BEATRIZ LEONOR
Resumen:
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A shared characteristic of tumor cells is their exacerbated growth. Consequently, tumor cells demand high rates of
phospholipid synthesis required for membrane biogenesis to support their growth. c-Fos, in addition to its AP-1
transcription factor activity, is the only protein known up to date that is capable of activating lipid synthesis in normal and
brain tumor tissue. For this latter activity, c-Fos associates to the endoplasmic reticulum (ER) through its N-terminal domain
and activates phospholipid synthesis, an event that requires it Basic Domain (BD) (aa 139?159). Fra-1, another member of
the FOS family of proteins, is over-expressed in human breast cancer cells and its BD is highly homologous to that of c-Fos
with two conservative substitutions