Efficacy of oral citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery. A local experience.

LAURA E. LARÓVERE

Revista de la Facultad de Ciencias Médicas de Córdoba

Facultad de Ciencias Médicas, Universidad Nacional de Córdoba

Lugar: Córdoba; Año: 2020 vol. 2020 p. 249 - 249

0014-6722

ulmonary hypertension (PH) is a major cause of morbi-mortality among patients with congenital heart disease (CHD) and also a potentially severe complication after surgical repair. Oral citrulline, a precursor to NO synthesis, is safe and efficacious for decreasing the risk of postoperative PH. Objective: The aim of the present study was to investigate the changes of plasma citrulline, arginine, homocysteine and nitric oxide (NO) metabolites and pulmonary artery pressures (PAP) pre-post cardiac surgery in order to describe our population status with regard to the risk of pulmonary hypertension and look for potential biomarkers for early detection and treatment. Main results/Discussion: 16 Argentine pediatric patients with CHD undergoing cardiopulmonary bypass were randomized in two groups: (A) with and (B) without perioperative citrulline supplementation. We found that plasma citrulline median levels before surgery were lower in both groups respect to referential values, probably due t