NÚÑEZ MONTOYA SUSANA CAROLINA
Artículos
Título:
"on-Demand" Antimicrobial Photodynamic Activity through Supramolecular Photosensitizers Built with Rose Bengal and (p-Vinylbenzyl)triethylammomium Polycation Derivatives
Autor/es:
VERA, CECILIA; GALLUCCI, MAURO N.; MARIONI, JULIANA; SOSA MORALES, MARCELO C.; MARTINO, DEBORA M.; NUÑEZ MONTOYA, SUSANA; BORSARELLI, CLAUDIO D.
Revista:
BIOCONJUGATE CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2022 vol. 33 p. 463 - 463
Resumen:
he antimicrobial photodynamic activity (aPDA) in fungal and bacterial strains of supramolecular adducts formed between the anionic photosensitizer (PS) Rose Bengal (RB2-) and aromatic polycations derived from (p-vinylbenzyl)triethylammonium chloride was evaluated. Stable supramolecular adducts with dissociation constants Kd≈ 5 μM showed photosensitizing properties suitable for generating singlet oxygen (φδ= 0.5 ± 0.1) with the added advantage of improving the photostability of the xanthenic dye. However, the aPDA of both free and supramolecular RB2-was highly dependent on the type of microorganism treated, indicating the importance of specific interactions between the different cell wall structures of the microbe and the PSs. Indeed, in the case of Gram-positive Staphylococcus aureus, the aPDA of molecular and supramolecular PSs was highly effective. Instead, in the case of Gram-negative Escherichia coli, only the RB2-:polycation adducts showed aPDA, while RB2-alo