Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches

CLEMENTE CAMILA MARA; ROBLEDO SARA M; RAVETTI SOLEDAD

BMC MEDICINE

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2022 vol. 22 p. 1 - 1

1741-7015

ntroduction: Despite the number of deaths and the signifcant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side efects and high toxicity for the patient. Therefore, there is an urgent need for safe, low-cost, and efective treatments. Natural products are an important source of bioactive compounds and there is current interest in fnding natural bioactive molecules that can be used for treating these parasitic diseases. In the present study we proposed to evaluate the in vitro antiparasitic activity of new menthol derivatives against Trypanosoma cruzi, Leishmania braziliensis and Plasmodium falciparum; moreover, we propose to explore their mode of action through in silico approaches.Material and methods: A series of carbonate prodrugs (1–9) were synthesized from menthol with diferent aliphatic alcohols. Spectroscopic techniques were used to confrm the structures of the synthesized compounds. T