Autor/es:
OLIVERO, NADIA B.; GONZALEZ-REICHE, ANA S.; RE, VIVIANA E.; CASTRO, GONZALO M.; PISANO, MARÍA B.; SICILIA, PAOLA; BARBAS, MARÍA G.; KHAN, ZENAB; VAN DE GUCHTE, ADRIANA; DUTTA, JAYEETA; CORTES, PAULO R.; HERNANDEZ-MORFA, MIRELYS; ZAPPIA, VICTORIA E.; ORTIZ, LUCIA; GEIGER, GINGER; RAJAO, DANIELA; PEREZ, DANIEL R.; VAN BAKEL, HARM; ECHENIQUE, JOSE
Resumen:
ackground: The SARS-CoV-2 virus is responsible for the COVID-19 pandemic. To better understand the evolution of SARS-CoV-2 early in the pandemic in the Province of Cordoba, Argentina, we performed a comparative genomic analysis of SARS-CoV-2 strains detected in survivors and non-survivors of COVID-19. We also carried out an epidemiological study to find a possible association between the symptoms and comorbidities of these patients with their clinical outcomes. Results: A representative sampling was performed in different cities in the Province of Cordoba. Ten and nine complete SARS-CoV-2 genomes were obtained by next-generation sequencing of nasopharyngeal specimens from non-survivors and survivors, respectively. Phylogenetic and phylodynamic analyses revealed multiple introductions of the most common lineages in South America, including B.1, B.1.1.1, B.1.499, and N.3. Fifty-six mutations were identified, with 14% of those in common between the non-survivor and survivor groups. Speci