Vitamin D levels and bone mass in rheumatoid arthritis

BRANCE ML; BRUN LR; LIOI S; SÁNCHEZ A; ABDALA M; OLIVERI B

SPRINGER

Lugar: Berlin; Año: 2015 vol. 35 p. 499 - 499

heumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease with high prevalence of osteoporosis. Previous evidence indicates an association between vitamin D deficiency and autoimmune diseases. The aim of this study was to evaluate serum 25 hydroxyvitamin D [25(OH)D] levels, bone mineral density (BMD) and disease activity in RA patients living in Argentina. We studied 34 RA women and 41 healthy women as a control group. RA patients had lower 25(OH)D levels (20.4±0.9 ng/ml) than controls (26.3±1.9 ng/ml; p<0.05). No significant differences were found in lumbar spine BMD between premenopausal (preM) or postmenopausal (postM) patients, but femoral neck BMD was significantly lower in postM RA patients (T-score -2.5±0.4) than in postM control subjects (T-score -0.9±0.3, p=0.014). Although no linear correlation between 25(OH)D levels and disease activity (DAS-28) was found, patients with moderate-high disease activity had lower 25(OH)D levels than those with low disea