Trabecular and cortical bone involvement in rheumatoid arthritis by DXA and DXA-based 3D modelling.

BRANCE ML; PONS-ESTEL BA; QUAGLIATO NJ; JORFEN M; BERBOTTO G; CORTESE N; RAGGIO JC; PALATNIK M; CHAVERO I; SOLDANO J; DIEGUEZ C; SÁNCHEZ A; DEL RIO L; DI GREGORIO S; BRUN LR

OSTEOPOROSIS INTERNATIONAL

SPRINGER LONDON LTD

Lugar: London; Año: 2021 vol. 32 p. 75 - 75

0937-941X

urpose: To evaluate cortical and trabecular bone involvement of the hip in rheumatoid arthritis (RA) patients by dual-energy X-ray absorptiometry (DXA) and 3D analysis. The secondary end-point was to evaluate bone involvement in patients treated with classic (c-DMARD) or biological (b-DMARD) disease-modifying antirheumatic drug therapies and the effect of the duration of the disease and corticosteroid therapy on 3D parameters.Methods: A cross-sectional study of 105 RA patients and 100 subjects as a control group (CG) matched by age, sex and BMI was carried out. Bone mineral density (BMD) was measured by DXA of the bilateral femoral neck (FN) and total hip (TH). The 3D analyses including trabecular and cortical BMD were performed on hip scans with 3D-Shaper software.Results: FN and TH BMD and trabecular and cortical vBMD were significantly lower in RA patients. The c-DMARD (n=75) group showed significantly lower trabecular and cortical vBMD than the CG. Despite the lower values, the b-