Pseudomyogenic hemangioendothelioma with bone and soft tissue involvement with favorable response to pamidronate: a case report and systematic review of the literature

BRANCE, MARÍA LORENA; CÓCCARO, NICOLÁS M.; ROITMAN, PABLO; CASTIGLIONI, ALEJANDRO; AGOSTINIS, FLORENCIA; SPENSE, MARIEL; SCHEITLIN, BÁRBARA; RENE, NICHOLAS; BRUN, LUCAS R.

Archives of Osteoporosis

Springer Science and Business Media Deutschland GmbH

Año: 2022 vol. 17

1862-3522

seudomyogenic hemangioendothelioma (PMH) can be a challenge for diagnosis and might be confused with other tumors, such as epithelioid sarcoma. Here we present a case and a systematic review of the literature to identify and discuss PMH treatment in primary bone involvement. A 25-year-old woman was referred for bone pain (10/10) in the left lower limb. Magnetic resonance imaging (MRI) showed multiple bone lesions (left femur, tibia, patella, ankle, and foot) with well-defined borders without signs of local aggressiveness. Positron Emission Tomography-Computed Tomography (PET-CT) showed multiple metabolic musculoskeletal lesions in the left lower limb. A CT scan?guided biopsy was performed. Histological and immunohistochemical findings confirmed the diagnosis of PMH. After treatment with intravenous pamidronate (90 mg/monthly), the patient had clinical improvement, mild pain 2/10 without the use of non-steroidal anti-inflammatory drugs or opiates. Follow-up was assessed by MRI and PET-