Effect of Teriparatide on Bone Mineral Density and Bone Markers in Real-Life: Argentine Experience

GUELMAN, RODOLFO; SÁNCHEZ, ARIEL; VARSAVSKY, MARIELA; BRUN, LUCAS R.; GARCÍA, MARÍA LAURA; SARLI, MARCELO; PAULA, REY; FARIAS, VANINA; ZANCHETTA, MARÍA BELÉN; GIACOIA, EVANGELINA; SALERNI, HELENA; MAFFEI, LAURA; PREMROU, VALERIA; OLIVERI, BEATRIZ; BRANCE, MARÍA LORENA; PAVLOVE, MAGDALENA; KARLSBRUM, SILVIA; LARROUDÉ, MARÍA SILVIA; COSTANZO, PABLO RENÉ

International Journal of Endocrinology

Hindawi Limited

Año: 2023 vol. 2023

1687-8337

urpose. To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials. Methods. Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months. Results. 264 patients were included in the study. Main characteristics are as follows: age: 68.7 ± 10.2 years, previous fractures: 57.6%, and previously treated with antiresorptive (AR-prior): 79%. All bone turnover markers studied significantly increased after 6 months. CTX and BGP remained high up to 24 months, but total and bone alkaline phosphatase returned to basal values at month 18. There was a significant increase in lumbar spine (LS) BMD after 6 months (+6.2%), with a maximum peak at 24 months (+13%). Femoral neck (FN) and total hip (TH) BMD showed a significant increase later than LS (just at month 12), reaching a maximum peak at month 24 (FN + 7.9% and TH + 5.5