Threshold based on bone mineral density for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy

BRANCE, MARÍA LORENA; LARROUDÉ, MARÍA SILVIA; SOMMA, LUIS FERNANDO; GIACOIA, EVANGELINA; DIEHL, MARÍA; GALICH, ANA MARÍA; RAMIREZ STIEBEN, LUIS AGUSTÍN; MAHER, MARÍA CIELO; DE LA VEGA, MARÍA; RINGER, ARIANA; BRUN, LUCAS R.

Reumatología Clínica

Sociedad Española de Reumatología (SER) y del Colegio Mexicano de Reumatología (CMR)

Año: 2023

1699-258X

ntroduction and aim: The T-score bone mineral density (BMD) thresholds might influence current guidance for treatment in patients under glucocorticoid (GC) therapy. Different BMD thresholds were described but there is no international consensus. The aim of this study was to find a threshold to help in the treatment decision in the population under GC therapy. Methods: A working group on behalf of three scientific societies from Argentina was convened. The first team was formed by specialists with expertise in glucocorticoid-induced osteoporosis (GIO) who voted according to summary of evidence. The second team was constituted by a methodology group who coordinated and supervised each stage. We conducted two systematic reviews to synthesize the evidence. The first included the trials of drugs used in GIO to analyze the BMD cut-off used as inclusion criteria. In the second one, we analyzed the evidence regarding the densitometric thresholds for fractured and non-fractured patients’ discr