BECERRA MARIA CECILIA
Artículos
Título:
AT 1 ‐R is involved in the development of long‐lasting, region‐dependent and oxidative stress‐independent astrocyte morphological alterations induced by Ketamine
Autor/es:
OCCHIEPPO, VICTORIA B.; BASMADJIAN, OSVALDO M.; MARCHESE, NATALIA A.; SILVERO, M.C. JAZMIN; RODRÍGUEZ, ANAHÍ; ARMONELLI, SAMANTA; BECERRA, M. CECILIA; BAIARDI, GUSTAVO; BREGONZIO, CLAUDIA
Revista:
EUROPEAN JOURNAL OF NEUROSCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2020
ISSN:
0953-816X
Resumen:
strocytes play an essential role in the genesis, maturation and regulation of the neurovascular unit. Multiple evidence support that astrocyte reactivity has a close relationshipto neurovascular unit dysfunction, oxidative stress and inflammation, providing a suitable scenario for the development of mental disorders. Ketamine has been proposed as a single‐use antidepressant treatment in major depression and its antidepressant effects have been associated with anti‐inflammatory properties. However, Ketamine long‐lasting effects over the neurovascular unit components remain unclear. Angiotensin II AT1 receptor (AT1‐R) blockers have anti‐inflammatory, antioxidant and neuroprotective effects. The present work aims to distinguish the acute and long‐term Ketamine effects over astrocytes response extended to other neurovascular unit components, and the involvement of AT1‐R, in prefrontal cortex and ventral tegmental area. Male Wistar rats were admini