Modulatory Effects Of Ghrelin On Sperm Quality Alterations Induced By A Fructose-Enriched Diet

MARTINI AC

Heliyon

Elsevier BV

Año: 2019

2405-8440

he objectives of this study were: 1) to evaluate the effects of a fructose enriched diet (FED) on rat3 sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) and4 testosterone concentrations; 2) to determine if the administration of ghrelin (Ghrl), reverses the5 effects induced by FED.6 After validating the protocol as an inductor of metabolic syndrome like-symptoms, adult male rats7 were assigned to one of the following treatments for 8 weeks: FED=10% fructose enriched diet (v/v);8 FED+Ghrl=fructose enriched diet plus Ghrl (6 nmol/animal/day, s.c.) from weeks 6 to week 8; or9 C=free access to food and water (n=5-10 animals/group).10 FED significantly decreased sperm concentration and motile sperm count vs C (FED:11 19.0±1.6x106sperm/ml and 834.6±137.0, respectively vs C: 25.8±2.8x106 and 1300.4±202.4,12 respectively; p