THE ROLE OF INTRAGESTATIONAL GHRELIN ON POSTNATAL DEVELOPMENT AND REPRODUCTIVE PROGRAMMING IN MICE

TORRES, PEDRO JAVIER; LUQUE, EUGENIA MERCEDES; PONZIO, MARINA FLAVIA; CANTARELLI, VERÓNICA; DIEZ, MARCELA; FIGUEROA, SILVIA; VINCENTI, LAURA MARIA; CARLINI, VALERIA PAOLA; MARTINI, ANA CAROLINA

REPRODUCTION

BIOSCIENTIFICA LTD

Año: 2018

1470-1626

he purpose of this study was to evaluate the intragestational role of ghrelin in offspring development and reproductive programming in a mouse model of ghrelin imbalance during pregnancy. Female mice were injected with ghrelin (supraphysiological levels: 4 nmol/animal/day), antagonist (endogenous ghrelin inhibition with (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control=normal ghrelin levels) throughout the pregnancy. Parameters evaluated in litters were growth, physical, neurobiological, and sexual development and, at adulthood, reproductive function. Litter size and initial weight did not vary between treatments. Male pups from dams treated with ghrelin showed higher body weight increase until adulthood (31.7±0.8 vs control=29.7±0.7, n=11-14 litters/treatment; p