Physicochemical characterization of physical mixture and solid dispersion of diclofenac potassium with mannitol

Rosario

Congreso; Segunda Reunión Internacional de Ciencias Farmacéuticas (RICIFA 2012); 2012

Fac. Bioquímica y Farmacia, UNR

Mannitol was used to increase the aqueous solubility and dissolution of different drugs (1-4) Diclofenac potassium has been classified as a class II drug as per the biopharmaceutical classification system (BCS) (5). The objective of the present work is to improve de dissolution profile of diclofenac potassium by formation of a physical mixture and a solid dispersion with mannitol. The solid dispersion was prepared by solvent method using ethanol/water. As diclofenac potassium melts with decomposition, the compatibility study with mannitol was done with the acid form by differential scanning calorimetry (DSC). The dissolution properties and physicochemical properties of diclofenac potassium:mannitol physical mixture and solid dispersion were investigated by dissolution test, X-ray diffractometry and infrared spectrometry.