Complexation between doxycycline hyclate and B-cyclodextrin. Experimental and theoretical studies

A. KOGAWA; A. ZOPPI; M. QUEVEDO; M. LONGHI; H. NUNES SALGADO

Ribeirao Preto. San Pablo

Congreso; 8th Internacional Congress of Pharmaceutical Sciences; 2011

USP

Doxycycline (DOX) is a drug effective against a large variety of bacteria. In addition, it has antiprotozoal actions and may be administered in conjunction with quinine in the management of falciparum malaria. Unfortunately DOX is quite susceptible to light, thus diverse strategies towards increasing its photostability are envisioned. A commonly applied approach to increase the stability of drugs is the formation of complexes with macromolecules, of which molecular encapsulation with β-cyclodextrin (βCD) constitutes an alternative for the development of new pharmaceutical dosage forms. The objective of this work was to investigate the possibility of obtaining an inclusion complex between DOX and βCD in order to enhance this drug stability, by combining both experimental and theoretical approaches.