MARTINI ANA CAROLINA
Congresos y reuniones científicas
Título:
Obesity, ghrelin and reproductive success in women under assisted reproductive technologies
Autor/es:
NOVILLO JM; HERNÁNDEZ M; ESTOFÁN D; ESTOFÁN P; MOLINA RI; DEMATEIS A; ESTOFÁN G; MARTINI AC
Lugar:
Tucumán
Reunión:
Congreso; Tercera Reunión de las Sociedades de Biología Argentinas; 2015
Resumen:
Female obesity has been associated with subfertility and, in some cases, with modifications in serum ghrelin (Ghr) concentrations. A recent clinical study reported a negative correlation between Ghr and embryo viability or cleavage. In this study, we aimed to investigate in women with indication of ICSI (intracitoplasmatic sperm injection), the possible association between Ghr, body mass index (BMI), other reproductive hormones and treatment success.We evaluated 75 women (from July 2014 to March 2015) that assisted to our fertility clinic (CIGOR). They were younger than 40, with no polichistic ovarian syndrome and their partners did not show evidences for severe male factor infertility. Thirty patients were normal, 29 were overweight (OW) and 16 were obese (OB). Patients? age or years of sterility did not vary between groups, and were 34.5±0.4 and 3.6±0.3 respectively. Serum Ghr was significantly higher in OB than OW (2559.7±297.9 vs 1695.3±182.4 pg/ml, p<0.05). With linear regression analysis, we found a negative association between BMI and basal concentrations of FSH (Coef.: -0,11), LH (Coef.: -0,12) or estradiol (Coef.: -1,78) and a positive association between BMI and insulin levels (Coef.: 0,68) or days of hormonal stimulation necessary to obtain adequate ovarian response (Coef.: 0,09). We didn´t find differences between groups in the number of oocytes retrieved, their maturity, fertilization index, embryo quality and cleavage or pregnancy percentages.In women under ICSI, BMI seems to be associated to reproductive hormonal alterations, but not to subfertility.