NÚÑEZ MONTOYA SUSANA CAROLINA
Congresos y reuniones científicas
Título:
Photo-inactivation mechanism over Candida biofilms by natural anthraquinones
Autor/es:
MARIONI J; BRESOLÍ-OBACH R; PARAJE MG; NONELL S; NÚÑEZ MONTOYA SC
Reunión:
Encuentro; 25th INTER-AMERICAN PHOTOCHEMICAL SOCIETY MEETING; 2016
Institución organizadora:
IAPS, Univer. Católica de Chile.
Resumen:
Two photosensitizing anthraquinones (AQs), isolated from Heterophyllaea pustulata Hook f. (Rubiaceae), rubiadin (AQ1) and 1-methyl ether rubiadin (AQ2), showed antifungal activity on Candida tropicalis biofilms under actinic irradiation. It was hypothesized that the photoinactivation mechanism involves the Reactive Oxygen Species (ROS): superoxide anion (O2?-) and/or singlet molecular oxygen (1O2). In this work, we set out to identify specifically the reactive intermediates involved.