Characterization of the Enalapril:βcyclodextrin complex in solid state. Study of the influence of the complexation on the stability of the drug Póster |
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Ariana Zoppi, Claudia Garnero, Yamila Garro Linck, Ana K. Chattah, Gustavo A. Monti and Marcela R. Longhi submetido por: Doctor en Ciencvias Químicas Garnero Claudia | |
Tópicos: "Polimorfismo""Cristalização" Palavras-Chave: enalapril, β-cyclodextrin, stability | |
Resumo | |
The main objective of this work was to study an inclusion complex between enalapril (ENA), and β-cyclodextrin (β-CD) in solid state. Inclusion complexes were prepared by liophilization method in the 1:1 molar ratio. The physical mixtures (PM) were also prepared in the same ratio. The full characterization of the complex was performed by powder x-ray diffraction, scanning electron microscopy and solid state nuclear magnetic resonance. These techniques confirmed the formation of an inclusion complex between ENA and β-CD in the solid state, as well as showed the amorphous nature of the solid obtained. When studying the chemical stability of ENA complexed to β-CD, a clear stabilizing effect was observed. |