DRUG DELIVERY SYSTEMS BASED ON POLYELECTROLYTE-DRUG-FATTY ACIDS TERNARY COMPLEXES FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS

GUZMAN MARIA LAURA; ARRIGONI, KAREN; MARIA E OLIVERA ME

Congreso; Reunión anual de Sociedades Biocientíficas en la que participarán 2019 (SAFE entre otras); 2019

Cutaneous Leishmaniasis is the most prevalent form of Leishmaniasis in South America. A topical treatment is attractive because of its potential to reduce side effects, increase patient compliance and its affordability. Risedronate (Ris) and Eudragit E (EE) have shown to be active against some forms of Leishmania. Previous studies showed that EuE-Ris complexes are promising candidates for topical administration. Besides they showed in vivo anti-Leishmania activity. The literature also describes the antileishmania activity for medium chain fatty acids.Our hypothesis is that the physicochemical properties of a new material EE-Ris-Capric Acid (CA) would allow to obtain nanometric compounds with enhanced antileishmania properties. The specific objectives of this work were: a) characterize physicochemically homologous series of EE-Ris-CA systems obtained and to evaluate the release properties of the loaded drug. For this, EE-Ris-CA obtaining method was tuned up and the zeta potencial, particle size and drug release profile from Franz cells towards water, NaCl, end PBS were assayed. All systems evaluated resulted in translucent, homogeneous and physically stable mixtures, which was considered an indicative aspect of the formation of a salt or complex between AC and the components of the EE-Ris complex. All pHs value were compatible with topical route (pH:5-6). When the molar proportion EE/CA was 1/1.2, the Z potential was considerably increased and there was also an increase in the proportion of 200nm particles (PDI>0.3). These results, could be attributed to a greater exposure of the basic groups of PE in comparison to EE-Ris system, that could indicate some change in the structures that were previously formed. When Ris kinetic release from EE-Ris-CA was evaluated, an increase in the Ris release was founded in all media tested with regard to EE-Ris, that would indicate a release mechanism dependent on ionic exchange; thus there is also reversible interaction between the components of the material.A new material containing antileishmanial drugs and excipients was obtained which would contribute to topical therapy to treat cutaneous leishmaniasis.