Fluoxetine revert memory impairment in a depressive animal models.

MARIA BELEN PORETTI; MARINA PONZIO; MARTA FIOL DE CUNEO; VALERIA PAOLA CARLINI

Cordoba

Congreso; II RCN. Second Joint Meeting of the Argentine Society for Neuroscience (SAN: XXV Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias) and the Argentine Workshop in Neuroscience (TAN: XII Taller Argentino de Neurociencias); 2010

Psychiatric disorders, including depression, are complex and heterogeneous clinical entities. The depressive state is characterized by a core conjunct of psychopathological phenomena, among which, the short and long-term memory impairment is included (Chestnut et al, 2008). The launch of fluoxetine (F) to the market, a selective serotonin reuptake inhibitor, was the beginning of a new era of safe and effective treatment for depression disease; nevertheless its impact upon memory processes has not been explained. In the present study we investigated its effects upon memory in a depression animal model (olfactory bulbectomy). Albino?s Swiss male mice were divided in two groups: sham (C) and bulbectomiced (BO). In order to determine a depressive behavior, after 15 days of surgery they were evaluated in tail suspension test and then, orally treated with saline (S) or F (10 mg/Kg) during 28 days. The last day of treatment, memory retention was evaluated using the objects recognition test. C-F and BO-S animals showed memory impairment in relation to C-S animals (F68,2= 39.5, p≤ 0.05), and BO-F animals showed memory enhancement in relation to BO-S (F134,4= 3.2, p≤ 0.05). In conclusion, F revert memory impairment in BO animals and, its effects varies according to the experimental model.