CLINICAL UTILITY OF ANTIMÜLLERIAN HORMONE REGARDING ANTRAL FOLLICLE COUNT IN THE EVALUATION OF THE OVARIAN RESPONSE

CAMILA FRAUTSCHI; MARIANA HERNANDEZ; ANA FLORENCE, STORK; CYNTHIA, CALICIO; CELINA, PALENA; ANA CAROLINA MARTINI; ANDREA, DEMATTEIS; VALERIA PAOLA CARLINI

Congreso; LXVIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC) XXV Jornadas Anuales de la Sociedad Argentina de Biología (SAB) LV Reunión Anual de la Asociación Argentina de Farmacología Experimental (AAFE) VIII Reunión Científica Region; 2023

Objectives: To analyze the total and mature number of oocytes recovered in women undergoing an assisted reproduction treatment (ART) who have discordant values of antimüllerian hormone concentrations (AMH) and antral follicle counts (AFC).Materials and Methods: 208 patients (35-39 years) who underwent ART at CIGOR between 2021 and 2022 were analyzed. Based on the cut-off values for AFC 5 and AMH 1.2 ng/ml, patients were divided according to the concordance/discordance of both values in 6 groups: AFC<5 and AMH<1.2 concordant or AMH≥1.2 discordant; AFC between 5-9 and AMH<1.2 discordant or AMH≥1.2 concordant; AFC≥10 and AMH<1.2 discordant or AMH ≥1.2 concordant. Mean±SD for the total and mature number of oocytes recovered were compared, and data analyzed by Mann-Whitney test, considering p<0.05 as significant.Results: For patients with a poor prognosis (AFC<5; N=51), 92% were concordant and only 8% discordant, with similar clinical results for both groups. In AFC≥10 (N=68), 87% of the patients presented concordant AMH and only 13% discordant, with significant differences in total oocytes (12.3 vs 6.4 ncordantly/discordantly respectively; p=0.0015) and mature oocytes (9.8 vs 5.4 concordantly/discordantly respectively; p=0.02). In the group with the AFC 5-9 (N=89), 28% were concordant (AMH≥1.2) and 71% were discordant (AMH<1.2), with statistically different results between the number of total oocytes (7.6 vs 4.7 concordantly/discordantly respectively; p=0.036) and that of mature oocytes (6.2 vs 3.7 concordantly/discordantly respectively; p=0.013).Conclusion: Considering both data (AFC and AMH) allows a better prediction of ovarian response, especially in those patients with AFC between 5-9 and discordant AMH values.