Heat killed cells of Cryptococcus neoformans var grubii induces protective immunity in rats: immunological and histopathological parameters

BARONETTI J; CHIAPELLO L; AOKI MP; GEA S; MASIH D

TAYLOR & FRANCIS LTD

Año: 2006 vol. 44 p. 493 - 493

font size="3" face="AdvTR"> Different clinical parameters which included cell-mediated immune (CMI) response, were evaluated in a model of disseminated cryptococcosis in rats. The experimental animals were pretreated four days prior to their exposure to Cryptococcus neoformans var. grubii with either heat killed cells of this yeastlike pathogen (HKC) or capsular polysaccharide (CPS) emulsified in complete Freund adjuvant (CFA). Rats treated with HKC-CFA and intraperitoneally infected with pathogen (HKC) or capsular polysaccharide (CPS) emulsified in complete Freund adjuvant (CFA). Rats treated with HKC-CFA and intraperitoneally infected with var.