Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection.

CARRERA SILVA, ANTONIO; GUIÑAZÚ, NATALIA; PELLEGRINI, ANDREA; CANO, ROXANA; AROCENA, ALFREDO; AOKI, MARIA DEL PILAR; GEA, SUSANA

PUBLIC LIBRARY SCIENCE

Año: 2010 p. 863 - 863

p style="margin: 0cm 0cm 0pt;" class="MsoNormal">Background: Toll-like receptors (TLR) and cytokines play a central role in the pathogen clearance as well as in pathological processes. Recently, we reported that TLR2, TLR4 and TLR9 are differentially modulated in injured livers from BALB/c and C57BL/6 (B6) mice during Trypanosoma cruzi infection. However, the molecular and cellular mechanisms involved in local immune response remain unclear. Methodology/Principal Findings: In this study, we demonstrate that hepatic leukocytes from infected B6 mice produced higher amounts of pro-inflammatory cytokines than BALB/c mice, whereas IL10 and TGFb were only released by hepatic leukocytes from BALB/c. Strikingly, a higher expression of TLR2 and TLR4 was observed in hepatocytes of infected BALB/c mice. However, in infected B6 mice, the strong pro-inflammatory response was associated with a high and sustained expres