Resumen:
p style="margin: 0cm 0cm 10pt; line-height: 150%;" class="MsoNormal">Myeloid-derived suppressor cells (MDSC), CD11b+Gr1+, are key players in the immune suppressive network. During acute infection with Trypanosoma cruzi, the causative agent of Chagas disease, BALB/c mice showed less inflammation and better survival than B6 ones. In this comparative study, we found a higher number of MDSC in spleen and liver of infected BALB/c than in B6 mice. An analysis of the two major MDSC subsets revealed a greater number of granulocytic cells in spleen and liver from BALB/c respect to B6 mice whereas the monocytic population was the predominant subset in the liver of both strains. Moreover, splenic MDSC purified from infected BALB/c mice inhibited ConA