Subchronic mycotoxicoses in rats. Histopathological changes and modulation of the sphinganine to sphingosine (Sa:So) ratio imbalance induced by fumonisin B1, due to the coexistence of aflatoxin B1 in the diet.

THEUMER, M; LOPEZ, AG; AOKI MP; CANEPA, MC; RUBINSTEIN, HR

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Elsevier; Año: 2008 vol. 46 p. 967 - 967

p class="MsoNormal" style="margin: 0cm 0cm 0pt;">Mycotoxicoses are diseases caused by consumption of diets contaminated with mycotoxins, a special class of fungal secondary metabolites. Fumonisin B1 (FB1) and aflatoxin B1 (AFB1), the main toxins synthesized by toxicogenic stocks of Fusarium spp. And Aspergillus spp., respectively, can coexist in grains and in its by-products. We investigated a probable synergism of a fumonisinscontaining Fusarium verticillioides culture material and AFB1 in the induction of hepatocyte apoptosis in rats subchronically fed on a mixture of them. Furthermore, the possibility of modifications in the fumonisins-induced Sa/So ratio imbalance in tissues and urine from rats poisoned with this mycotoxin, due to the presence of AFB1 in the diet, was evaluated. The co-exposure to fumonisins and AFB1 produced a higher liver toxicity, with respect to their individual administration, inducing apoptosis and mitotic he