Clomipramine and Benznidazole act synergistically and ameliorate the outcome of experimental Chagas disease: In vivo and in vitro assessments

GARCÍA, MC; PONCE, NE; SANMARCO, LM; MANZO, R; JIMENEZ KAIRUZ, A; AOKI, MP

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AMER SOC MICROBIOLOGY

Lugar: Washington; Año: 2016 vol. 60

0066-4804

!--[if gte mso 9]> Chagas disease is animportant public health problem in Latin America, and its treatment by chemotherapywith benznidazole (BZ) or nifurtimox remains unsatisfactory. In order to designnew alternative strategies to improve the current etiological treatments, inthe present work, we comprehensively evaluated the in vitro and in vivo anti-Trypanosoma cruzi effect of clomipramine(CMP, a parasite-trypanothione reductase-specific inhibitor) combined with BZ.In vitro