Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein

AOKI MP; CANO RC; PELLEGRINI AV; TANOS T; GUIÑAZÚ NL; COSO OA; GEA S

ELSEVIER SCIENCE BV

Año: 2006 vol. 8 p. 1723 - 1723

p style="line-height: 200%; margin: 0cm -33.75pt 0pt 0cm;" class="MsoNormal">            We have recently reported that Trypanosoma cruzi infection protects cardiomyocytes against apoptosis induced by growth factor deprivation. Cruzipain, a major parasite antigen, reproduced this survival effect by a Bcl-2 dependent mechanism. In this study, we investigated the molecular mechanisms of cruzipain-induced cardiomyocyte protection.             Neonatal BALB/c mouse cardiac myocytes were cultured under minimum serum conditions (0.1% FBS) in presence of cruzipain (10 ug/ml) or T. cru