MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes

DEBORAH HODGE; DELLA REYNOLDS; FABIO CERBAN ; SILVIA CORREA ; NATALIA BAEZ ; HOWARD YOUNG ; MARIA CECILIA RODRIGUEZ GALAN

EUROPEAN JOURNAL OF IMMUNOLOGY

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2012 vol. 42 p. 1 - 1

0014-2980

ature lymphocyte immigration into the thymus has been documented in mouse, rat,and pig models, and highly increases when cells acquire an activated phenotype. Entranceof peripheral B and T cells into the thymus has been described in healthy and pathologicalsituations. However, it has not been proposed that leukocyte recirculation to thethymus could be a common feature occurring during the early phase of a Th1 inflammatory/infectious process when a large number of peripheral cells acquire an activated phenotypeand the cellularity of the thymus is seriously compromised. The data we presenthere demonstrate that in well-established Th1 models triggered by different types ofimmunogens, for example, LPS treatment (a bacterial product), Candida albicans infection(a fungus), and after Trypanosoma cruzi infection (a parasite), a large number of matureperipheral B and T cells enter the thymus. This effect is dependent on, but not exclu