High dissemination and hepatotoxicity in animals infected with C.albicans: potencial sensitization to liver damage after stress exposure

CORREA SG; RODRIGUEZ GALAN MC; SALIDO-RENTERÍA B; CANO R; CEJAS H; SOTOMAYOR CE

OXFORD UNIV PRESS

Año: 2004 vol. 16 p. 1761 - 1761

he liver constitutes the first barrier in the control of hematogenous dissemination for Candidaalbicans of intestinal origin. The ability of this organ to limit the growth of the yeast and to mount anefficient inflammatory reaction is crucial in determining the outcome of the fungal infection. Whenrats infected with C. albicans are exposed to chronic varied stress, the cell recruitment is impaired at the site of the infection, the tissue reaction is highly disorganized in target organs and the infectionevolution is more severe. At hepatic level, higher fungal burden is associated with hyphal form andthe consistent presence of steatosis (fatty liver). Herein we aimed at characterizing the steatosisassociated with C. albicans infection and to provide molecular evidence of the correlation among liver injury markers, stress products and the initiation of the inflammatory tissue reaction. After 3 days of stress and infection, we observed micro and macro