Phenotypic and functional changes on phagocytic cells recruited at the site of Candida albicans infection after chronic varied stress exposure

RODRIGUEZ GALAN MC; CORREA SG; IRIBARREN P; SOTOMAYOR CE

TAYLOR & FRANCIS LTD

Año: 2002 vol. 40 p. 485 - 485

The transition of Candida albicans from commensalism to pathogenicity isassociated with the immune status of the host; resistance to fungus involvesmacrophages (Mf) and polymorphonuclear neutrophils (PMN), which act aseffector cells. T-cell function is also involved. Previously, we found that in Wistarrats exposed to chronic varied stress (CVS) immediately after C. albicans infection(Ca-S group) some functions of phagocytic cells, such as killer activity and NOproduction, were strongly modiŽed compared with unstressed, infected animals (Cagroup). We examined the phenotypic and functional changes of these effector cellsrecruited at the site of C. albicans infection. The recruitment of peritoneal cells (PC)was markedly reduced in Ca-S animals and the arrival of Mf and PMN was selectively diminished after CVS exposure. The integrin CD11b/CD18, implicated in migration and C. albicans phagocytosis, was downregulated in Mf of Ca-S anima