Impaired activity of phagocytic cells in Candida albicans infection after exposure to chronic varied stress

RODRIGUEZ GALAN MC; CORREA SG; CEJAS H; SOTOMAYOR CE

KARGER

Año: 2001 vol. 9 p. 193 - 193

andidiasis is a prototypic opportunistic fungal disease that may follow severe modulations of theimmune system of the host. The purpose of this study was to evaluate which innate immune mechanisms involved in the protection against fungal invasion are impaired under stress conditions. Methods: Wistar rats were infected intraperitoneally with Candida albicans and immediately exposed to chronic varied stress (CVS) over 10 days (CVS; Ca-S); the fungal burden (CFU), histopathological lesion and ACTH levels were evaluated. Additionally, functional assessment of peritoneal cells (PC) included the phagocytic and anticandidacidal activities and the production of H2O2 and NO. Results: In the only infected animals (Ca), C. albicans colonization stimulatedan efficient inflammatory response, while in Ca-S rats poor tissue reactions were associated with increased CFU in livers and kidneys (p <0.05, Ca vs. Ca-S). Whereas the phagocytic process was not modified, the candidacidal activ