Nanoparticle-cored dendrimers: functional hybrid nanocomposites as new platform for drug delivery systems

VERONICA BRUNETTI; LYDIA M. BOUCHET; MIRIAM C. STRUMIA

Nanoscale

RSC

Año: 2015 vol. 7 p. 3808 - 3808

2040-3364

anoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriersbecause of their colloidal stability, tunable membrane properties and ability to encapsulate orintegrate a broad range of drugs and molecules. This kind of hybrid nanocomposite aims tocombine the advantage of stimuli-responsive dendritic coating, in order to regulate the drug release behaviour under different conditions and improve the biocompatibility and in vivo halftimecirculation of the inorganic nanoparticles. Size, surface chemistry and shape are keynanocarrier properties to evaluate. Here, we have reviewed the most recent advances of NCDsin drug delivery systems, compared their behaviour with non-dendritic stabilized nanoparticlesand highlighted their challenges and promising applications in the future.