More than Just Size: Challenges and Opportunities of Hybrid Dendritic Nanocarriers

RIMONDINO, GUIDO; OKSDATH-MANSILLA, GABRIELA; BRUNETTI, VERÓNICA; STRUMIA, MIRIAM

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2017 vol. 23 p. 1 - 1

1381-6128

p>Background: Dendrimers and hyperbranched polymers are emerging polymer architectures that attractincreasing attention due to their unique topological structure and interesting physicochemical properties. Their enormouspotential makes them particularly attractive to form new and fascinating nanometric drug delivery systems,solving several typical shortcomings encountered in nanomedicine.Objective: In this context, the recent developments of dendritic and hyperbranched based systems, together with theirapplication as nanocarriers, have been comprehensively reviewed.Conclusion: This review highlights how the structural complexity can be taken as an evolution parameter of thesenanosystems, starting with hyperbranched polymers and evolving to more complex structures such as hybrid dendritic-inorganic nanoparticles and dendronized nano-objects hierarchically designed. Finally, future directions andperspectives in this promising field are briefly discussed.