Peptide-Based Biomaterials. Linking L-Tyrosine and Poly L-Tyrosine to Graphene Oxide Nanoribbons

JOSÉ M. GONZÁLEZ-DOMÍNGUEZ; FABIANA A. GUTIÉRREZ; JAVIER HERNÁNDEZ; ALEJANDRO ANSON-CASAOS; MARÍA D. RUBIANES; GUSTAVO A. RIVAS ; M. TERESA MARTÍNEZ

Journal of Materials Chemistry B

Royal Society of Chemistry

Lugar: Cambridge; Año: 2015 vol. 3 p. 3870 - 3870

2050-750X

p style="margin: 0cm 0cm 0pt; text-indent: 0cm;">Peptide-based biomaterials are being studied actively in a variety of applications in materials science and biointerface engineering. Likewise, there has been ongoing exploration over the last few decades into the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements and in gene therapy and biosensing. The resent study proposes different strategies for the bonding of L-tyrosine and the homopolypeptide poly- L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment of L-tyrosine was undertaken by amidation of the a-amine group