Identification of Giardia lamblia DHHC proteins and the role of protein S-palmitoylation in the encystation process

MERINO MC; ZAMPONI N; VRANYCH CV; TOUZ MC; ROPOLO AS

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2014 vol. 8 p. 2997 - 2997

font face="AdvP403A40" size="1"> Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we analyzed the presence of DHHC proteins in the protozoa parasite Giardia lamblia and the function of the reversible S-palmitoylation of proteins during parasite differentiation into cyst. Two specific events were observed: encysting cells displayed