CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice

MALETTO, BELKYS ANGELICA; ANDREA SILVANA ROPOLO; MORON G; PISTORESI, MARIA CRISTINA

FEDERATION AMER SOC EXP BIOL

Año: 2002 vol. 72 p. 447 - 447

b> We examined whether CpG-DNA could be used as adjuvant to induce a T helper cell type-1 (Th1) immunity in aged BALB/c mice that showed a Th2 polarization. Bordetella pertussis and complete Freund’s adjuvant (CFA) were used as well. Immunization with ovalbumin (OVA)/CpG-DNA showed that the immunoglobulin G (IgG)2a/IgG1 ratio and OVA-specific T cell response were similar in young and aged mice. OVA/CpG-DNA induced the secretion of interferon-