A Giardial ENTH protein regulates vacuolar homeostasis and reveals an exceptional bifunctional role in clathrin-mediated trafficking

CONSTANZA FELIZIANI; NAHUEL ZAMPONI; NATALIA GOTTIG; ANDREA RÓPOLO; ADRIANA LANFREDI-RANGEL; MARIA CAROLINA TOUZ

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 1854 p. 646 - 646

span lang="en" style="line-height: 115%; font-family: "Times New Roman","serif"; font-size: 12pt; mso-ansi-language: EN-US; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">In the protozoa parasite Giardia lamblia, endocytosis and lysosomal protein trafficking are vital parasite-specific processes that involve the action of the adaptor complexes AP-1 and AP-2 and clathrin. In this work, we have identified a single gene in Giardia encoding a protein containing an ENTH domain that