The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the Vacuolar protein sorting receptor

MIRAS S; MERINO MC; GOTTIG, N; RÓPOLO A; TOUZ MC

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013 vol. 1833 p. 2628 - 2628

p class="MsoNormalCxSpFirst" style="margin: 1em 0px 0pt; text-align: justify; line-height: 150%; mso-add-space: auto; mso-layout-grid-align: none;">The retromer is a pentameric protein complex that mediates the retrograde transport of acid hydrolase receptors between endosomes and the trans-Golgi network and is conserved across all eukaryotes. Unlike other eukaryotes, the endomembrane system of Giardia trophozoite is simple and is composed only of the endoplasmic reticulum and peripheral vesicles (PVs), which may represent an ancient organellar system converging compartments such as early and late endosomes and lysosomes. Sorting and trafficking of membrane proteins and soluble hydrola