Involvement of Nitric Oxide in Protecting Mechanism during experimental cyptococcosis

GABRIELA ROSSI, LAURA CERVI, MARÍA M GARCÍA, LAURA CHIAPELLO, DARÍO SASTRE, DIANA T. MASIH

CLINICAL IMMUNOLOGY

IDEAL. Academic Press

Año: 1999 vol. 90 p. 256 - 256

1521-6616

b> In the present study we investigated the role of nitric oxide (NO) in the effector mechanisms of host defense against Cryptococcus neoformans in vivo. Our results showed an increase of NO produced by the peritoneal macrophages from 14-days infected rats compared with normal rats. These cells were capable of killing C. neoformans to a greater extent than macrophages from noninfected rats (80% vs 20%, respectively). The killing of C. neoformans by infected cells was efficiently inhibited (80% to 35%, P < 0.00