Immunization of rats against Fasciola hepatica using crude

LAURA CERVI, JANINA BORGONOVO, MARIELA EGEA, LAURA CHIAPELLO, DIANA MASIH*

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Elsevier

Año: 2004 vol. 97 p. 97 - 97

0165-2427

font face="AdvP41153C" size="1"> Chronic Fasciola hepatica infection is correlated with the development of a T helper (Th2)-predominant immune response. To determine whether immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODN) or Freund?s complete adjuvant (FCA), known to promote a Th1 (T helper 1) immune responses, could provide protection from F. hepatica infection, total homogenate (TH) of F. hepatica mixed with CpG-ODN or FCA were injected subcutaneously (s.c.) into Wistar rats. A F. hepatica-specific Th1-predominant immune response was induced with CpG-ODN or FCA in lymph nodes of immunized